PRIMERA REUNIÓN - MARTES 29 NOVIEMBRE 2011

Nuestra primera reunión fue todo un exito, asistieron la mayoría de los residentes de Ginecología y Obstetricia de la Universidad del Sinú, el relator fue el doctor Renato Castaño, el articulo era un meta análisis sobre pulsos de maduración pulmonar de un grupo de investigación en Australia.


O B S T E T R I C S
Repeat antenatal glucocorticoids for women at risk of preterm birth: a Cochrane Systematic Review
Christopher J. D. McKinlay, MBChB; Caroline A. Crowther, MD; Philippa Middleton, MPH; Jane E. Harding, DPhil



Administration of antenatal glucocorticoids to women at risk of preterm birth has major
benefits for infants but the use of repeat dose(s) is controversial. We performed a systematic review of randomized trials, using standard Cochrane methodology, to assess the
effectiveness and safety of 1 or more repeat doses given to women at risk of preterm birth
7 or more days after an initial course. Ten trials were included involving over 4730 women
and 5700 infants. Treatment with repeat dose(s) compared with no repeat treatment
reduced the risk of respiratory distress syndrome (risk ratio, 0.83; 95% confidence interval, 0.75– 0.91) and serious neonatal morbidity (risk ratio, 0.84; 95% confidence interval,
0.75– 0.94). At 2- to 3-year follow-up (4 trials, 4170 children), there was no evidence of
either significant benefit or harm. Repeat doses of glucocorticoids should be considered in
women at risk of preterm birth 7 or more days after an initial course, in view of the neonatal
benefits.
Key words: prenatal corticosteroids, repeat antenatal glucocorticoids, respiratory distress syndrome, systematic review.

DIRECTOR: JAIME BARRIOS NASSI MD ESP